DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

More than two hundred metabolic enzymes, many of which are normally tasked with producing energy in the mitochondria, are also found sitting directly on top of human DNA, according to a study ...

Scientists discovered hundreds of energy-making enzymes secretly working on human DNA—revealing a hidden “mini-metabolism” ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health ...

A 19-year-old Canadian man becomes the first human cured through prime gene editing after doctors corrected a rare genetic ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

A deeper understanding of how DNA changes over generations helps scientists learn why people differ and how diseases develop. Until recently, many fast-changing parts of the human genome remained ...

NAD+ is a critical coenzyme for cellular energy production, DNA repair, and sirtuin activity, with levels known ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice. The findings reveal a previously ...

Artificial intelligence is rapidly becoming medicine’s most powerful microscope, revealing patterns in human DNA that were invisible to doctors and researchers only a few years ago. Instead of ...